Opening this week on Jan. 21, Isaac's Barbecue, a new joint by chef Isaac Starobin of Dirty Dog Barbeque, a favorite at Manifesto Market Anděl, in the heart of New Town will challenge any superficial conceptions of American cuisine. Tuck into lamb birria tacos, gochujang bbq pork bao buns, and smoked brisket sliders, all washed down with signature cocktails and local microbrews.