These Czech startups are solving real-world problems in 2026

A casual conversation sparked the creation of Kardi Ai, a pocket-sized heart monitor developed in Czechia, where cardiovascular disease remains the leading cause of death.

Over a glass of wine, entrepreneur Stephen Burke and cardiologist Tomáš Skála discussed how existing tools miss patients needing long-term heart monitoring. Irregular rhythms often appear unpredictably, while standard 24-hour ECGs capture only a fraction of cases, delaying diagnosis and increasing the risk of stroke or heart failure.

The company’s solution combines a wearable chest strap, mobile app, and cloud platform that uses AI to analyze ECG data continuously. Users can track heart activity during daily life and receive structured results within minutes. “We are shifting cardiology from reactive diagnostics to continuous prevention,” explains CEO Vlastimil Hrabal.

The product is available in English, allowing expats to monitor their heart health without navigating the local system. In one case, a user named Pavel detected atrial fibrillation during a routine check, after years of inconclusive tests.

“I would occasionally feel irregular heartbeats, but nothing ever showed up,” he said. “Kardi Ai helped detect a serious health problem early, when it could still be treated in time.”

When vital information is spread across documents, systems, and teams, it slows decision-making and creates compliance risks. This is especially a concern in sectors that depend on traceable information.

“Important knowledge is often scattered across systems, which makes it difficult to find reliable answers quickly,” explains Hajo Libor, CEO of Phi Technologies. “Our platforms turn that information into actionable insight.”

Libor and his team developed a platform that uses AI-driven knowledge systems, including governed retrieval-augmented generation, to allow organizations to search, analyze, and automate workflows across their own data. The tools currently support a government ministry in Germany in advising small and medium-sized businesses on regulatory compliance in medical device development.

Czechia has provided a stable foundation for long-term development, supported by strong engineering talent and continuity dating back to the 1990s. While the company is based here, it operates in English by default, an essential choice for organizations with global ambitions in Central Europe.

"The AI products support a wide range of languages, with English as a core requirement, alongside German, Czech, and other languages," says AI lead Hana Grubhofferová. She adds that prioritizing English ensures accessibility for international teams and expats working in knowledge-intensive roles.

Preventive healthcare remains underused because screenings are time-consuming, unclear, and often disconnected from daily life. However, according to researcher Petr Štěpánek, “most health issues are treatable if you start early."

Formed in 2021, Macromo offers at-home blood testing combined with AI-driven analysis of more than 50 biomarkers. Štěpánek, alongside colleagues Eva Kuttichová and Michal Pohludka, developed an algorithm linking biological data to detect disease risk. "We make that process simple and accessible," he emphasizes.

Users receive results through an app, along with a personalized plan covering nutrition, supplements, and lifestyle changes. They can retest over time to track progress. A typical user might test for deficiencies or risk factors, then adjust diet and habits based on clear recommendations rather than generic advice.

Czechia offered an innovative environment to develop personalized longevity services, along with strong links to labs and medical experts. “Longevity should not be limited to a small group,” the team says. “Our goal is to make it mainstream and affordable.”

The platform is fully available in English and serves customers across the EU, making it easy for expats to access preventive care without relying on local systems.

Building a website or app still requires technical knowledge that most people lack, even with existing AI tools. “Most people hit a wall when they need to deal with code or infrastructure,” explains Macaly co-founder Petr Brzek. “We remove that barrier entirely.”

Brzek, along with co-founders Martin Ďuriš and Tomáš Rychlík, created Macaly after their earlier startup was acquired. It prompted a shift toward simplifying how people build online products.

The company uses an AI agent that turns plain-language prompts into fully functional websites or apps, complete with hosting, databases, analytics, and SEO. “You can describe what you want and have it live on your own domain in one click,” Brzek adds. “That changes who gets to build online.”

A founder can launch an MVP in minutes, while a marketer can create a campaign page without developers. Internal tools, such as HR dashboards or client portals, are built directly through conversation with the AI technology.

The team focused on Czechia first, using it as a testing ground to refine the product before scaling across Europe through its parent company. The platform runs in English, with a large user base in the U.S., making it accessible to international teams.